Post-translational Control of Innate Immune Signaling Pathways by Herpesviruses

Post-translational Control of Innate Immune Signaling Pathways by Herpesviruses

Blog Article

Herpesviruses constitute a large family of disease-causing DNA viruses.Each herpesvirus strain is capable of infecting particular organisms with a specific cell tropism.Upon infection, pattern recognition receptors (PRRs) recognize conserved viral features to trigger signaling cascades that culminate in the production of interferons and pro-inflammatory Compressor Motor Overload Cutout cytokines.

To invoke a proper immune response while avoiding collateral tissue damage, signaling proteins involved in these cascades are tightly regulated by post-translational modifications (PTMs).Herpesviruses have developed strategies to subvert innate immune Vitamin B signaling pathways in order to ensure efficient viral replication and achieve persistent infection.The ability of these viruses to control the proteins involved in these signaling cascades post-translationally, either directly via virus-encoded enzymes or indirectly through the deregulation of cellular enzymes, has been widely reported.

This ability provides herpesviruses with a powerful tool to shut off or restrict host antiviral and inflammatory responses.In this review, we highlight recent findings on the herpesvirus-mediated post-translational control along PRR-mediated signaling pathways.